Hong Kong Exchanges and Clearing Limited

FORM 2 - Corporate Substantial Shareholder Notice

Form Serial Number:

CS20260923E00377

1. Date of relevant event:

18/09/2026
(dd/mm/yyyy)

2. Date when the substantial shareholder becomes aware of the relevant event / interest in the shares (if later):

22/09/2026
(dd/mm/yyyy)

3. Stock code:

03696

4. Name of listed corporation:

InSilico Medicine Cayman TopCo

5. Class of shares:

Ordinary Shares

6. Number of issued shares in class:

582,684,110

7. Name of substantial shareholder:

JPMorgan Chase & Co.

8. Registered office:

270 Park Avenue, New York, New York, NY, 10017, United States

9. Principal place of business in Hong Kong:

N/A

15. Exchange on which listed:

New York Stock Exchange

16. Name of listed parent and exchange on which parent is listed:

N/A

17. Details of relevant event:

Brief description of relevant event

Capacity in which shares were/are held

Number of shares bought/sold or involved

Currency of transaction

On Exchange

Off Exchange

Before relevant event

After relevant event

Highest price (per share)

Average price (per share)

Average consideration (per share)

Nature of consideration

Long position

1101	The percentage level of your interest in the shares has increased because: you purchased the shares

2201	Interest of corporation controlled by you

2201	Interest of corporation controlled by you

5,865,983

HKD

60.8000

59.2930

59.0751

3101

Cash

Short position

18. Total shares immediately before the relevant event:

	Total number of shares	Percentage figure (%)
Long position	35,341,968	6.06
Short position	15,912,285	2.73
Lending Pool	15,529,414	2.66

19. Total shares immediately after the relevant event:

	Total number of shares	Percentage figure (%)
Long position	41,207,951	7.07
Short position	17,396,730	2.98
Lending Pool	16,379,414	2.81

20. Capacity in which interests disclosed in Box 19 are held:

Capacity code

Number of shares

2101	Beneficial owner

Long position	21,640,188
Short position	17,396,730

2102	Investment manager

Long position	18,500
Short position	0

2106	Person having a security interest in shares

Long position	3,169,849
Short position	0

2502	Approved lending agent

Long position	16,379,414
Short position	0

21. Further information in respect of derivative interests:

Derivatives code

Number of shares

4105	Unlisted derivatives - Physically settled

Long position	37,080
Short position	74,160

4106	Unlisted derivatives - Cash settled

Long position	2,085,526
Short position	11,664,032

4103	Listed derivatives - Convertible instruments

Long position	5,700,322
Short position	269,998

22. Further information in relation to interests of corporations controlled by substantial shareholder:

Name of controlled corporation

Address and place of incorporation

Name of controlling person

% control

Direct interest (Y/N)

Number of shares

J.P. Morgan Securities LLC

270 Park Avenue New York NY 10017 United States

J.P. Morgan Broker-Dealer Holdings Inc.

100.00

Long position	805,700
Short position	130,705

JPMorgan Asset Management (China) Company Limited

42F&43F 479 Lujiazui Ring Road China (Shanghai) Pilot Free Trade Zone Shanghai 200120 China

JPMorgan Asset Management Holdings Inc.

100.00

Long position	18,500
Short position	0

Almea 2 Segregated Portfolio Company

270 Park Avenue New York NY 10017 United States

J.P. MORGAN MARKETS LIMITED

100.00

Long position	408
Short position	0

J.P. Morgan Prime Inc.

270 Park Avenue New York NY 10017 United States

J.P. Morgan Securities LLC

100.00

Long position	5,500
Short position	5,500

J.P. Morgan SE

TaunusTurm Taunustor 1 Frankfurt am Main Frankfurt 60310 Germany

J.P. Morgan International Finance Limited

100.00

Long position	134,999
Short position	134,999

JPMorgan Chase Bank, National Association

1111 Polaris Parkway Columbus OH 43240 United States

JPMorgan Chase & Co.

100.00

Long position	16,379,414
Short position	0

J.P. MORGAN SECURITIES PLC

25 Bank Street Canary Wharf London E14 5JP England

J.P. MORGAN CAPITAL HOLDINGS LIMITED

100.00

Long position	23,863,430
Short position	17,125,526

J.P. Morgan Broker-Dealer Holdings Inc.

4 Chase Metrotech Center 4th Floor Brooklyn NY 11245 United States

JPMorgan Chase Holdings LLC

100.00

Long position	811,200
Short position	136,205

JPMorgan Chase Holdings LLC

270 Park Avenue New York NY 10017 United States

JPMorgan Chase & Co.

100.00

Long position	830,108
Short position	136,205

JPMorgan Asset Management Holdings Inc.

270 Park Avenue New York NY 10017 United States

JPMorgan Chase Holdings LLC

100.00

Long position	18,500
Short position	0

J.P. MORGAN MARKETS LIMITED

25 Bank Street Canary Wharf London E14 5JP England

J.P. MORGAN FINANCIAL INVESTMENTS LIMITED

100.00

Long position	408
Short position	0

J.P. MORGAN FINANCIAL INVESTMENTS LIMITED

25 Bank Street Canary Wharf London E14 5JP England

JPMorgan Chase Holdings LLC

100.00

Long position	408
Short position	0

J.P. Morgan Securities LLC

270 Park Avenue New York NY 10017 United States

J.P. Morgan Broker-Dealer Holdings Inc.

100.00

Long position	5,500
Short position	5,500

J.P. Morgan International Finance Limited

270 Park Avenue New York NY 10017 United States

JPMorgan Chase Bank, National Association

100.00

Long position	23,998,429
Short position	17,260,525

JPMorgan Chase Bank, National Association

1111 Polaris Parkway Columbus OH 43240 United States

JPMorgan Chase & Co.

100.00

Long position	23,998,429
Short position	17,260,525

J.P. MORGAN CAPITAL HOLDINGS LIMITED

25 Bank Street Canary Wharf London E14 5JP England

J.P. Morgan International Finance Limited

100.00

Long position	23,863,430
Short position	17,125,526

23. Further information in relation to interests held by substantial shareholder jointly with another person:

Name of joint shareholder	Address	Number of shares

24. Further information from a trustee, a beneficiary of a trust, or a person who set up a discretionary trust:

Names of trust	Address	Status code	Number of shares

25. Further information from a party to an agreement under Section 317 (Please see Notes for further information required):

Names of other parties	Address	Number of shares

Total number of shares in which a substantial shareholder is interested under sections 317 and 318

26. Details of person(s) in accordance with whose directions the substantial shareholder or its directors are accustomed to act:

Names	Address	Relationship Code	Percentage (%)

27. Supplementary information:

28. Log/Serial Number of the previous form:

29. Number of concert party document(s) under section 317 attached/uploaded:

Date of filing this Form 2:

23/09/2026
(dd/mm/yyyy)